【摘 要】
：
目的：确定妊娠第1 8周的母体血清C-反应蛋白与早产、胎膜早破的相关性.方法：采用前瞻性队列研究的方法,在我院妇产科门诊测定189例孕妇第18周的血清CRP水平,并随访至分娩结束.统计足月妊娠、未足月胎膜早破、早产的发生例数,分成三组：足月妊娠组、未足月胎膜早破组、早产组.整理相关数据后,使用SPSS 21软件来进行统计分析.结果：在189例产妇中,足月妊娠166例,未足月胎膜早破8例,早产23例
【出 处】
：
2015中国医师协会妇产科医师大会
论文部分内容阅读
目的：确定妊娠第1 8周的母体血清C-反应蛋白与早产、胎膜早破的相关性.方法：采用前瞻性队列研究的方法,在我院妇产科门诊测定189例孕妇第18周的血清CRP水平,并随访至分娩结束.统计足月妊娠、未足月胎膜早破、早产的发生例数,分成三组：足月妊娠组、未足月胎膜早破组、早产组.整理相关数据后,使用SPSS 21软件来进行统计分析.结果：在189例产妇中,足月妊娠166例,未足月胎膜早破8例,早产23例.未足月胎膜早破组、早产组比足月妊娠组的平均CRP水平高,分别为16.97±6.82 mg/L、14.87±5.89mg/L和6.36±2.55mg/L.足月产组和未足月胎膜早破组的妊娠第18周母体CRP水平有显著性差异,最佳界值为13.5mg/L.足月产组和早产组的妊娠第1 8周母体CRP水平有显著性差异,最佳界值为11.6mg/L.对于早产组,以11.6mg/L作为临界检测值,检测的灵敏度为73.9％,特异度为98.2％,OR：11.35,95％CI：1.05-122.77.对于未足月胎膜早破,以13.5mg/L作为临界检测值,检测的灵敏度为62.5％,特异性为98.8％,OR： 10.90,95％CI：1.05-116.27.结论：妊娠期母体血清中的CRP水平与早产和未足月胎膜早破有相关性；妊娠中期母体血清中的CRP的值超过一定的临界值,早产和未足月胎膜早破风险将显著增加；妊娠中期母体血清中的CRP的值可用来作为预测早产和未足月胎膜早破的一项指标.
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