THE STIMULATOR OF INTERFERON GENES PLAYS AN IMPORTANT ROLE IN KSHV LIFE CYCLE

来源 :17th International Workshop on Kaposi’s Sarcoma Associated H | 被引量 : 0次 | 上传用户：liongliong533

【摘要】

：

The stimulator of interferon genes (STING;also known as TMEM173, MPYS, MITA and ERIS) is a critical signaling molecule in innate immune response to cytosolic nu

【作者】

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Hongtao Xu Liang He Hongyu Deng

【机构】

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ChineseAcademyofSciencesKeyLaboratoryofInfectionandImmunity,InstituteofBiophysics,ChineseAcademyofSc

【出处】

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17th International Workshop on Kaposi’s Sarcoma Associated H

【发表日期】

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2014年7期

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The stimulator of interferon genes (STING;also known as TMEM173, MPYS, MITA and ERIS) is a critical signaling molecule in innate immune response to cytosolic nucleic-acid ligands.STING responds to the cytosolic presence of dsDNA and cyclic-dinucleotides by relocalizing to discrete foci from endoplasmic reticulum in the cell cytoplasm.This relocalization is associated with recruitment and activation of the kinase TBK1, which phosphorylates IRF3, leading to induction of type I interferon expression.

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THE STIMULATOR OF INTERFERON GENES PLAYS AN IMPORTANT ROLE IN KSHV LIFE CYCLE

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