HPE方案治疗常规方案失败的非小细胞肺癌

来源 :中国抗癌协会临床肿瘤学协作中心第五届学术年会 | 被引量 : 0次 | 上传用户:jinwei001
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目的:探讨羟基喜树碱(HCPT)、顺铂(CDDP)和足叶已甙(Vp-16)联合治疗常规方案(CAP)失败的晚期非小细胞肺癌疗效. 方法:43例非小细胞肺癌接受CAP方案2~4周期治疗失败后改用HPE化疗,HCPT 6mg/m2 ivgtt d1-5,CDDP 100mg/m2 ivgtt 分2天使用d1,2,Vp-16 100mg d1-5,28天为一周期,每例化疗2周期观察疗效和毒副反应. 结果:经2周期治疗后鳞癌有效率44.8%,腺癌有效率35.7%,总有效率41.9%.毒副反应主要是白细胞下降和胃肠道反应. 结论:HPE方案是治疗常规方案失效的非小细胞肺癌疗效较高的方案,尤其对基层医院复治病例可考虑使用.
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