Pharmaceutical Cocrystals to Modify Physico-chemical and Dissolution Profile of APIs

• 作 者: AshwiniNangia;
• 机 构: School of Chemistry University of Hyderabad India
• 出 处: 中国上海第七届国际新药发明科技年会
• 发表日期: 2009年期

　　Pharmaceutical cocrystals,or the hydrogen-bonded crystalline complex between an API and a benign co-former (preferably from the GRAS list),offer rational approaches to make new supramolecular entities for drug deliver and formulation.Crystal engineering principles for cocrystal synthesis through robust heterosynthons have been developed for drugs containing carboxylic acid,carboxamide,sulfonamide,alcohol,amine functional groups with complementary co-formers such as pyridine,pyridine-N-oxide,acid,amide,etc.A major advantage of cocrystals over traditional salts is that APIs containing non-ionizable functional groups are amenable to solid-state control and modification of properties,such as hydration,ambient stability,dissolution,color,tableting.