MICRORNA-31 REGULATE PHENOTYPIC MODULATION OF HUMAN VASCULAR SMOOTH MUSCLE CELL VIA ITS TARGET GENE

来源 :第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int | 被引量 : 0次 | 上传用户:sogood1918
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objectives Cellular repressor of E1A-stimulated genes (CREG) plays an important role in phenotypic modulation of VSMCs,but the mechanism of its upstream signalling regulation is not clear.Recently, microRNAs (miRNA) have been found to play a critical role in cell differentiation and proliferation, suggesting that miRNA may be an upstream regulator of CREG.
其他文献
Objectives Small interfering RNA (siRNA) methodology suppresses specific gene expression, thus mimicking loss-of-function mutation and enabling in vitro and in vivo gene function analysis.siRNA techno
会议
Objectives To study the expression Prohibitin in proliferation vascular smooth muscle cells (VSMCs) after balloon injure in rat carotid artery.Methods Twenty-four male SD rats of SPF grade were random
会议
Objectives To investigate the correlation between C171T mutation of the potassium inwardly-rectifying channel, subfamily J,member 5 (KCNJ5) gene, and the hypokalemic primary aldosteronism (PA).Methods
会议
Objectives To investigate the effects of activation of Autophagy on cerebral injury after cardiopulmonary resuscitation (CPR) in Wistar rat.Methods First 36 healthy adult male Wistar rats were induced
会议
Objectives This study aimed to test the protection of puerarin in oxidative stress-induced mitochondrial injury in rat cardiac H9c2 cells.Methods Rat heart tissue-derived H9c2 cells were used.First, w
会议
Objectives To investigate the myocardial proliferation/regeneration and myocardial cell apoptosis during different time points and in different parts of the heart in acute myocardial infarction (AMI)
会议
Objectives CD36, a class B scavenger receptor expressed on macrophages mediates uptake of oxLDL and contributes to foam cell formation, a hallmark of early atherosclerosis.Tobacco smoking is a major r
会议
Objectives To investigate the effects of advanced glycation endproducts (AGEs) on apoptosis and telomere length of human adiposetissue-derived stem cells (ADSCs) and the related molecular mechanism.Me
会议
Objectives In ventricular fibrillation, the uncoupling of gap junctions slows conduction velocity and increases action-potential dispersion, which slows and diminishes defibrillation.We studied how th
会议
Objectives To study the effect of activated β3-AR on reverse cholesterol transport and arterial atherosclerotic plaques in apolipoprotein E knockout (ApoE-/-) mice.Methods Ten wide type C57BL/6J mice,
会议