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Objectives To study the effect of activated β3-AR on reverse cholesterol transport and arterial atherosclerotic plaques in apolipoprotein E knockout (ApoE-/-) mice.Methods Ten wide type C57BL/6J mice, 10 weeks old, were used as the normal control group.Fifty 10-week-old ApoE-/-mice were fed a high-fat diet until 36 weeks old.