Effects of preconditioning on brain endothelial cells tight junctions and cell adherence

• 作 者: PingAN;Yi-XueXUE;
• 机 构: Department of Neurobiology, College of Basic Medicine, China Medical University, Shenyang 110001, Ch
• 出 处: 中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
• 发表日期: 2007年期

　　Objective Stroke is a kind of health-threatening disease especially for the older people.The mechanism of stroke has been studied deeply,but is not fully understood and the treatment measures are not well satisfactory.Preconditioning with brief,nonlethal ischemia (ischemic preconditioning,IPC) can reduce the injury of subsequent severe ischemia.This phenomenon is called ischemia tolerance.The precise mechanism of brain ischemia tolerance is unclear and a lot of substances may have been involved in the process.Blood-brain barrier (BBB) is composed of brain microvascular endothelial cells,basal membrane and glial cell processes,and which is important to hold the balance between brain tissue and blood.During brain ischemia,the disruption of BBB results in the increase of brain vascular permeability and it could further promote ischemic brain injury and brain edema.Brain microvascular endothelial cells are characterized by the presence of tight junctions and the absence of fenestrations and vesicles.After brain ischemia,the tight junctions of BBB are disrupted,transcytosis vesicles are increased,and leukocytes adherence and migration rate is enhanced.