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Vascular disease increases in incidence with age and is the commonest cause of morbidity and mortality among elderly people.Large-conductance Ca2+-activated K+ (MaxiK) channel, with pore-forming a-subunit and modulatory β1-subunit, is a key regulator of vascular tone.Any change in activity or expression of MaxiK channel would affect vascular functions.This study explored functional and molecular evidence of MaxiK alteration with aging in the mesenteric artery (MA).Male Wistar rats of three ages were used (Young, 4-5M;Middle-aged, 15-16M;and Old, 22-24M).