实验性缺血性脑损伤与NRG1-ErbB4通路关联性研究

来源 :中国神经科学学会第九届全国学术会议暨第五届会员代表大会 | 被引量 : 0次 | 上传用户：hongxu815

【摘要】

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【作者】

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卢应梅韩峰李可心陈晓娟陶蓉蓉黄继云李晓明

【机构】

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浙江大学医学院,卫生部神经生物学重点实验室,杭州310058 浙江大学药理毒理与生化药学研究所,杭

【出处】

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中国神经科学学会第九届全国学术会议暨第五届会员代表大会

【发表日期】

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2011年1期

【关键词】

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神经调节素 ErbB4 缺血性脑损伤神经保护

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　　目的神经调节素Neuregulin 1(NRG1)和它的受体ErbB信号通路在神经元的生长、分化和存活中具有重要作用.但是NRG1-ErbB4在缺血性脑损伤中迟发性神经元死亡中的作用和机制并不清楚.本研究的目的是探讨NRG1-ErbB4关联信号对缺血性脑损伤引起的迟发性神经元死亡的保护作用及其机制.方法综合应用多种分子生物学、形态学和行为学等多种研究手段展开研究,应用Western blotting技术定量检测脑组织中ErbB4蛋白表达的经时变化,应用激光共聚焦免疫荧光技术验证缺血性脑损伤后ErbB4蛋白在神经元细胞的表达变化.结果 NRG1对原代培养小鼠皮层神经元细胞结合缺氧缺糖条件下诱发的神经元细胞损伤有一定保护作用.NRG1脑室给药(ALZET(R)MICRO-OSMOTIC PUMP)可以有效减少脑梗塞灶的体积,NRGl的脑保护作用与ErbB4受体调控机制关联.结论 NRG1的神经保护作用可能是通过干预ErbB4关联信号途径来实现的.

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实验性缺血性脑损伤与NRG1-ErbB4通路关联性研究

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