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Aim: Cardiac hypertrophy is regarded as a clinical determinant of heart failure.The average age of cardiac hypertrophy onset is his/her 50s and the average patient with heart failure is late 70s.This leaves a relatively large time window where a patient displaying early cardiac hypertrophy could be treated to slow or even prevent the progression of hypertrophic remodeling; therefore studies to discover regulatory mechanisms underlying hypertrophic remodeling and to identify potential therapeutic targets for treating heart failure are of paramount importance.