Ischemic injury promotes Keap1 nitration and disturbance of antioxidative responses in endothelial c

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：sonic0824

【摘要】

：

Aim: Accumulating evidence implicates that the endothelial injury contributes to the ischemic neurovascular damage.This study is to assess role of Keap1/ Nff2 associated downstream nitric oxide redox

【作者】

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Rong-rong TAO Quan JIANG Mei-hua LIAO Ling-juan HONG Yun TIAN Jing-jing CAO Jia-jia PAN Feng HAN Ying-mei LU

【机构】

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Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, Zhejiang University, Hangzhou,

【出处】

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The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

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2013年4期

【关键词】

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endothelial cells Keap1 melatonin oxygen-glucose deprivation S-nitrosylation tyr

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Aim: Accumulating evidence implicates that the endothelial injury contributes to the ischemic neurovascular damage.This study is to assess role of Keap1/ Nff2 associated downstream nitric oxide redox signaling in ischemia-induced endothelial cells injury.Methods: EA.hy926 cells were exposed to oxygen-glucose deprivation (OGD) for 1, 3, 6, and 12 h.S-nitrosylation content of Keap1 protein was determined by biotin-switch method using the protein S-nitrosylation detection kit.

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Ischemic injury promotes Keap1 nitration and disturbance of antioxidative responses in endothelial c

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