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OBJECTIVE Xiao-xu-rning decoction (XXMD),a well-known traditional Chinese herbal prescription, has been widely used to treat stroke.It is recorded in "Bei Ji Qian Jin Yao Fang" written by Si-miao Sun of the Chinese ancient Tang Dynasty.In our previous study, the active fraction of XXMD (XXM) against cerebral ischemia has been prepared by modern separation and purification techniques.