Emergence of Outward Kir2.1 Currents Balance of High and Low-affinity Polyamine Blocks

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户:linmu22952
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Outward currents through Kir2.1 channels play crucial roles in controlling the electrical properties of excitable cells, and such currents are subjected to voltage-dependent block by intracellular Mg2+ and polyamines that bind to both high-and low-affinity sites on the channels.Under physiological conditions, high-affinity block is saturated and yet outward Kir2.1 currents can still occur, implicating that high-affinity polyamine block cannot completely eliminate outward Kir2.1 currents.
其他文献
Cocrystals · are crystals that contain two or more different molecular components · components are solids at room temperature · often rely on hydrogen-bonded
会议
Ertapenem Sodium, (INVANZ(R))Courtesy of (O).Almarsson, M.Kaufman and D.Dubost INVANZ(R) sterile lyophlllzed product contains:Ertapenem sodium 1 g, sodium bicar
会议
Key Questions · Can cocrystals form as a result of stresses encountered during pharmacautical processing and storage?· How to maintain a desired cocrystal for
会议
Andrew Cassity Catherine Gardner Ernest Chow Mark Eddleston Erica Bithell Graeme Day Tomislav Friscic Andrew Trask Shyam Karki Bhavnital Patel Kreso Dejan-Bucar
会议
明胶-氧化铅灌注技术被誉为整形外科界皮瓣血管解剖研究的"金标准",但应用此方法研究血管形态亦有不足之处:(1)铅是对人体及环境毒性最大的重金属之一;(2)明胶属于热填充剂,
会议
Outline · Crystal forms, developability , impact on oral drugs · Why cocrystals?· Landscape prior to 2002 and the decade of 2002-2012 Historical examples and
会议
随机抽取120例拉萨藏族大学生,进行跟骨骨密度和身体成分的检测.计算和比较骨密度及其与身体成分的相关性.结果显示,随着年龄的增长,骨密度T值呈下降趋势,男女峰值均出现在25
会议
咬合重建是通过改变患者长期存在的低位咬合和原有的咬合状态,重建新的合(牙合)位和咬合关系,对恢复患者咬合功能和改变面部形态起到至关重要的作用.随着MRI和三维重建技术在
会议
深入探讨经方补阳还五汤治疗缺血性脑卒中的抗氧化机制是指导该方合理有效用药的基础.本实验从14 d胎鼠中获取胚胎神经干细胞,经无血清培养基悬浮培养并传代.取传3代神经干细
会议
调查福建汉族闽东语族群692人(城市男性151人,乡村男性188人,城市女性159人,乡村女性194人)成人的86项体质指标,对26项体质指数进行计算,统计指数分型情况,并与我国族群资料
会议