【摘 要】
：
Cocrystals · are crystals that contain two or more different molecular components · components are solids at room temperature · often rely on hydrogen-bonded
【机 构】
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DepartmentofPharmaceuticalSciencesUniversityofMichiganAnnArbor,Michigan
【出 处】
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2013 International Symposium on Pharmaceutical Solid-State R
论文部分内容阅读
Cocrystals · are crystals that contain two or more different molecular components · components are solids at room temperature · often rely on hydrogen-bonded assemblies between neutral molecules of the active pharmaceutical ingredient (API) and other components · are a homogenous (single) crystalline phase with well-defined stoichiometries AB, AB2, etc Cocrystals · Technological innovation-Molecular level design of crystals with multiple components-Develop large number of cocrystals for a given drug · Motivation for cocrystal discovery-Enhanced product performance, controlled delivery-IP protection, lifecycte management, etc · Customize material properties-Solubility-Dissolution-Bioavailability
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