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Background, Motivation and Objective Ultrasound contrast agents (UCAs) have been recently studied for drug delivery applications, since cavitation can increase the temporary permeability of nearby cells. However, the internal volume of UCA is generally filled with gas, hence loading drug molecules into UCAs is limited. In this study, a type of echogenic liposome having a liquid and gas core is proposed as an alternative carrier of genetic material for ultrasound-mediated drug delivery.