【摘 要】
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Background, Motivation and Objective Functionalised nanoparticles (NP) have been shown to enable delivery of small silencing RNA molecules (siRNA) to cancer cells, disabling proliferation and providin
【机 构】
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School of Engineering, University of Glasgow, Glasgow, United Kingdom
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Background, Motivation and Objective Functionalised nanoparticles (NP) have been shown to enable delivery of small silencing RNA molecules (siRNA) to cancer cells, disabling proliferation and providing a route to therapy. However the approach can be restricted to specific cell lines, limiting translation potential to in vivo treatment [1]. Here, we investigate delivery of NP to human breast cancer cell lines (MCF7), previously proven problematic in this regard, using ultrasound (US) and microbubbles (MB). In particular we examine potential mechanisms of NP delivery, opportunities for optimisation and offer insight to cellular recovery post treatment.
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