Hesl Defends Normal Hematopoietic Stem Cells Against T Cell Leukemic Environment

• 作 者: TianChen[1]LiQiao[2]CaoZhipan[2]ZhengGuo-guang[2]YuanWei-ping[2]ChengTao[2]
• 机 构: Department of Hematology,Tianjin Medical University Cancer Institute and Hospital
• 出 处: 肿瘤多学科综合诊治新进展学术研讨会
• 发表日期: 2012年期

　　Objective In T-ALL leukemia mouse model,the impacts of leukemic environment on normal HSC and HPC were distinct in that normal HSCs were preserved in part because of increased mitotic quiescence of HSCs and resulted exhaustion of HPC proliferation.Our current work is to further explore the molecular mechanism of leukemic environment on normal HSCs.