论文部分内容阅读
Rapid developments in the life science have increased the need for novel sophisticated instrumental techniques, that should provide capabilities for deeper insight into processes at molecular and nano levels.The scientists in the field of analytical chemistry have put a lot of efforts in developing new miniaturized instrumental techniques applicable in flow-format.In this study the main focus has been put on the development of open tubular capillary electrochromatographic techniques for the elucidation of nanoscale functions of lipoproteins and their protein-free derivatives.Full understanding of atherosclerosis at the molecular level requires unraveling of the changes of molecular interactions during atherogenesis.These nanoscale interactions influence the metabolism of the lipoprotein particles in the arterial wall by affecting the interactions of lipoproteins with the components of the extracellular matrix.