人工RNA特异性内切酶的设计并构造

来源 :第十一届全国酶学学术讨论会暨邹承鲁诞辰90周年纪念会 | 被引量 : 0次 | 上传用户：dianquan999

【摘要】

：

RNA的转录后加工处理在细胞的基因表达中占很重要的地位,因此特异性的控制RNA代谢可以用来调控基因表达和发展基因疗法.然而,自然界的RNA内切酶通常不具有序列特异性.而细胞

【作者】

：

Rajarshi Choudhury 王泽峰

【机构】

：

DepartmentofPharmacologyandLinebergerComprehensiveCancerCenter,UniversityofNorthCarolina,ChapelHill,

【出处】

：

第十一届全国酶学学术讨论会暨邹承鲁诞辰90周年纪念会

【发表日期】

：

2013年5期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

RNA的转录后加工处理在细胞的基因表达中占很重要的地位,因此特异性的控制RNA代谢可以用来调控基因表达和发展基因疗法.然而,自然界的RNA内切酶通常不具有序列特异性.而细胞内RNA的特异性剪切通常是由复杂的蛋白复合体来催化的,这些复合体的特异性是要由反义RNA来决定.因此,设计一种特异性降解RNA的简单蛋白酶成为一个挑战.

其他文献

FoxO1蛋白的翻译后修饰与细胞自噬

Autophagy is activated to maintain cellular energy homeostasis in response to nutrient starvation.However, autophagy is not persistently activated, which is poo

会议

Cyclooxygenases Are Homodimers That Function as Conformational Heterodimers That Are Allosterically

Prostaglandin endoperoxide H synthases (PGHSs)-1 and-2, also known as cyclooxygenases (COXs)-1 and-2, convert arachidonic acid (AA; 20:4 ω-6) to prostaglandin

会议

15-Deoxy-△-12,14-prostaglandin J2, an electrophilic lipid mediator of proinflammatory and anti-infla

15-Deoxy-△12,14-prostaglandin J2(15d-PGJ2) has been known to display multifaceted cellular functions, including anti-inflammatory and cytoprotective effects.Ho

会议

Aurora B promotes the interaction between Ataxin-10 and Plk1 in cytokinesis

Spinocerebellar ataxia type 10 (SCA10) is an autosomal dominant neurologic disorder caused by ATTCT expansion in the ATXN10 gene.Previously we have presented da

会议

苏云金芽胞杆菌中DUF2762超家族的一个未知结构域执行holin功能

穴蛋白(holin)是有尾的双链DNA噬菌体编码的一种跨膜蛋白质,它与内溶素配合对细菌进行裂解.根据拓扑异构学可将穴蛋白分为三大类(第Ⅰ类、第Ⅱ类和第Ⅲ类),它们具有不同的作

会议

15-Hydroxyprostaglandin Dehydrogenase as a Putative Suppressor of Inflammation-Associated Carcinogen

15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is the key enzyme that catalyzes the first step i n the inactivation of prostaglandin E2 (PGE2), and hence consi

会议

Dysfunction of CD11b+Gr1high myeloid cells in allergen-induced airway hyperresponsiveness triggered

Myeloid-derived suppressor cells (MDSCs) have been implicated in many pathologic conditions including asthma, but their regulation in aspirin (ASA)-intolerant a

会议

THE ROLE OF EP RECEPTORS IN BLOOD PRESSURE REGULATION

Hypertension is a risk factor for cardiovascular diseases and is the leading cause of chronic kidney disease.Prostaglandin E2 (PGE2), a potent lipid mediator wi

会议

The cytochrome P450 epoxygenasesoluble epoxide hydrolase axis in endothelial signalling and vascular

Fatty acid epoxides are important lipid signaling molecules involved in the regulation of vascular tone and homeostasis.Tissue and plasma levels of these mediat

会议

Discovery of a potent benzoxaborole-based antipneumococcal agent targeting leucyl-tRNA synthetase

　　Aminoacyl-tRNA synthetases have been attractive antibiotic drug targets for their fundamentality in cellular translation.Benzoxaboroles are recently develop

会议

人工RNA特异性内切酶的设计并构造

其他学术论文