Construction of intracellular drug delivery system with high efficiency based on Poly- β- malic acid

• 作 者: S.Y.Guo;Q.Zhou;M.F.Cui;H.Wu;
• 机 构: Department of Pharmaceutical Analysis,School of Pharmacy,Fourth Military Medical University,Xi'an 7
• 出 处: 中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议
• 发表日期: 2014年期

　　TAT is a kind of synthesized peptide that is able to carry large molecules into cells independent of classical endocytosis,which has been widely used in the research of tumor drug delivery.But its' non-selective penetrating could make the drug carriers get into normal cells.In order to decrease the killing of normal cells,we use Poly-β-malic(PMLA)acid modified with TAT and longer cleavable PEG5000 linked with pH-sensitive hydrazine bond.Poly(ethylene glycol)(PEG)is the most commonly used coating material with non-fouling property.