Exploring androgen receptor as a new treatment target in Her2-Driven Breast Cancer

来源 :2015中国转化医学大会暨中国转化医学联盟成立大会 | 被引量 : 0次 | 上传用户：qidezhong

【摘要】

：

　　The androgen receptor (AR) is expressed in approximately 60% of Her2+ breast cancers (BC).However, the functional role of AR is less well understood in Her2

【作者】

：

Zhuanyun Du Jennifer Richer Nicholas D'Amato Haihua Gu

【机构】

：

Department of Basic Laboratory Medicine, School of Laboratory Medicine and life Science Wenzhou Medi

【出处】

：

2015中国转化医学大会暨中国转化医学联盟成立大会

【发表日期】

：

2015年期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　The androgen receptor (AR) is expressed in approximately 60% of Her2+ breast cancers (BC).However, the functional role of AR is less well understood in Her2+ BC.Activated AR can elicit transcriptional upregulation of Her3.

其他文献

The Biological Function of Pyruvate Dehydrogenase in Cancers

　　Pyruvate dehydrogenase (PDH) is the multi-enzyme complex of mitochondrion.Its catalysis is of great importance in the process of energy metabolism.PDH catal

会议

谷氨酰胺酶的活性检测和肿瘤个性化治疗的探索

　　肿瘤细胞基因突变，特别是糖酵解中的丙酮酸激酶肌肉同工酶剪切变构体2(PKM2)突变，可导致葡萄糖有氧糖代谢途径的明显改变，即Warburg效应：葡萄糖代谢增加200倍，但产物乳酸被排

会议

Methylation of DACT2 accelerates esophageal cancer development by activating Wnt signaling

　　Esophageal cancer is one of the most common malignancies worldwide.DACT2 is frequently methylated in human lung, hepatic, gastric and thyroid cancers.The me

会议

Expression of Pim-1 in salivary gland adenoid cystic carcinoma: association with tumor progression a

　　As a highly malignant tumor, salivary gland adenoid cystic carcinoma (ACC)accounts for nearly 10% of all the epithelial salivary tumors and with a low 5-yea

会议

The novel focal adhesion gene Kindlin-2 promotes the invasion of gastric cancer cells mediated by tu

　　Kindlin-2 is a novel focal adhesion gene mediating the cell-ECM (extra-cell matrix) adhesion.Tumor associated macrophages (TAMs) plays an important role in

会议

Low Concentrations of Chloroquine and 3-Methyladenine Suppress the Viability of Retinoblastoma Cells

　　Background: To study the inhibition of retinoblastoma cell viability by two commonly usedautophagy inhibitors, chloroquine (CQ) and 3-methyladenine (3-MA),a

会议

Curcumol triggers apoptosis of p53 mutant, triple-negative human breast cancer cell MDA-MB 231 via a

　　Background: Triple-negative breast cancer (TNBC) remains a major challenge clinically due to a lack of biological targets and aggressive disease course.Curc

会议

　　食管癌是我国常见的高发病率、高死亡率的恶性肿瘤。目前,国内外针对食管癌化疗抵抗性的机制研究均着眼于食管癌细胞本身,而忽略了肿瘤微环境的影响。肿瘤相关纤维细胞作

会议

Sox2 communicates with Tregs through Ccl1 to promote the stemness property of breast cancer cells

　　As an important component of tumor microenvironment, CD4+ CD25+ Tregs reduce antitumor immunity and promote angiogenesis and metastasis in breast cancer.

会议

雌激素受体α、DNMT1和DNMT3b和乳腺癌细胞耐药

　　雌激素受体α(estrogen receptor,ERα)是一种类固醇激素受体,在超过60％的乳腺癌中表达.临床观察和回顾性分析均显示ERα阳性的乳腺癌更易产生化疗药物耐受.近年来ERα与

会议

Exploring androgen receptor as a new treatment target in Her2-Driven Breast Cancer

其他学术论文