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Myxobacteria are Gram-negative, rod-shaped aerobic bacteria which have astonishing lifecycles and upon starvation, undergo cellular morphogenesis converting to resistant myxospores which are multicellular fruiting bodies.[l] Over the past two decades, these organisms have gained attention as an excellent source of bioactive compounds with novel structures.[2] We have developed a research program directed towards the total synthesis of myxobacteria metabolites which has resulted in the synthesis of several of these molecules.[3-5] Current targets are the rhizopodin and the anticancer spiroketal spirodienal A.In this presentation, our recent progress towards the synthesis of some of these metabolites will be presented.