低剂量毒死蜱重复染毒对幼鼠神经发育及空间学习记忆的影响

来源 :全国卫生毒理学术研讨会 | 被引量 : 0次 | 上传用户：hillyblue

【摘要】

：

目的毒死蜱(Chlorpyrifos,CPF)是我国推荐使用的低毒有机磷农药,其大量应用对环境造成持续污染,而儿童比成年人有更多的暴露机会和更高的生物易感性,可产生更为严重的神经毒性作用.本研究通过对幼龄大鼠重复染毒,探讨CPF的神经发育毒性.方法对新生雄性大鼠施以连续灌胃染毒(PNDl-21),染毒剂量为不引起动物出现明显有机磷中毒症状的低剂量(0.3、1、3mg/kg),溶剂对照组给予同溶

【作者】

：

闫长会陈爽秦川叶小娥关勇彪

【机构】

：

军事医学科学院毒物药物研究所国家北京药物安全评价与研究中心抗毒药物与毒理学国家重点实验室北京100850

【出处】

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全国卫生毒理学术研讨会

【发表日期】

：

2014年9期

【关键词】

：

毒死蜱神经发育毒性低剂量空间记忆

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