Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during

来源 :全国卫生毒理学术研讨会 | 被引量 : 0次 | 上传用户：hhugjl012800

【摘要】

：

【作者】

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Ye-Fa Zhang Wei He Cheng Zhang Xiao-Jing Liu Yah Lu Hua Wang Zhi-Hui Zhang Xi Chen De-Xiang Xu

【机构】

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Department of Toxicology,Anhui Medical University,Hefei,China

【出处】

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全国卫生毒理学术研讨会

【发表日期】

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2014年9期

【关键词】

：

Acetaminophen necroptosis receptor-interacting protein (RIP) kinases apoptosis-i

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　　Acetaminophen (APAP) overdose induces apoptosis-inducing factor (AIF)-dependent necroptosis,but the mechanism remains obscure.The present study investigated the role of receptor interacting protein (RIP)l,a critical mediator of necroptosis,on AIF-dependent necroptosis during APAP-induced acute liver failure.Mice were intraperitoneally injected with APAP (300 mg/kg).As expected,hepatic RIP 1 was activated as early as 1 h after APAP,which is earlier than APAP-induced hepatic RIP3 upregulation.

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Role of receptor interacting protein (RIP)1 on apoptosis-inducing factor-mediated necroptosis during

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