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  5. Concatenated Alpha4 Beta2 Nicotinic Receptors as Tools to Develop Receptor Selective Ligands

Concatenated Alpha4 Beta2 Nicotinic Receptors as Tools to Develop Receptor Selective Ligands

来源 :2013第四届国际神经科技大会 | 被引量 : 0次 | 上传用户：liongliong591
【摘 要】
：
　　Nicotinic ACh receptor (nAChR) α4 and t2 subunits assemble in two alternate stoichiornetries to produce (α4β2)2α4 and (α4β2)232, which display differe
【作 者】
：
Isabel Bermudez 
【机 构】
：
OxfordBrookesUniversityUK
【出 处】
：
2013第四届国际神经科技大会
【发表日期】
：
2013年5期
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　　Nicotinic ACh receptor (nAChR) α4 and t2 subunits assemble in two alternate stoichiornetries to produce (α4β2)2α4 and (α4β2)232, which display different agonist sensitivities.Functionallyrelevant, agonist binding sites are thought to be located at α4 (+)/β2 (-) subunit interfaces but because these interfaces are present in both receptor isoforms, it is unlikely that they account for differences in agonist sensitivities.
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