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It is little known that also European countries like Austria have tradition in neurophysiological integrative medicine research, especially Traditional Chinese Medicine (TCM) including acupuncture research.For over 15 years, the research concerning high-tech acupuncture has been playing an important role at the Medical University in Graz.Within this keynote lecture, a short summary concerning different innovative techniques for bioengineering assessment of peripheral and central effects of acupuncture is presented.