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Objective: Previous studies reported that the location of the center of rotation (COR) at instrumented level after cervical total disc replacement (TDR) deviated from its preoperative location.However, currently, it is unknown whether the deviated COR is linked to the range of motion (ROM) at instrumented level.The purpose of this study was to evaluate the clinical outcomes after cervical TDR with ProDisc-C and investigate the location change of the COR at instrumented level and its clinical significance.Methods: A total of 23 patients who underwent single-level cervical TDR with ProDisc-C were included.Japanese Orthopaedic Association (JOA) score and Neck Disability Index (NDI) were used to assess clinical outcomes.Radiographic parameters such as cervical ROM, instrumented segmental ROM, adjacent segmental ROM and intervertebral height were analyzed.