Approaching the channelopathies associated with epilepsy by natural sodium channel-specific modulato

• 作 者: Yong-HuaJI;
• 机 构: Lab Neuropharmacol.Neurotoxicol., Shanghai University, Shanghai 200444, China
• 出 处: 中国神经科学学会第九届全国学术会议暨第五届会员代表大会
• 发表日期: 2011年期

　　Voltage-gated sodium channel plays an indispensable role in the initiation and propagation of the action potential.Alterations of sodium channel properities are associated with several neurological pathogenetic disorders such as epilepsy, movement disorder, ataxia, inherited pain and so on.Many drugs such as phenytoin, carbamazepine, lamotrigine and sodium valproate targeting on sodium channels have been widely applied in clinical antiepileptic therapies currently.In thus study, unique sodium channel site3/4-specific modulators from Asian scorpion Buthus martensi Karsch (BmK) were investigated to have capabilities of either kindling convulsant or anticonvulsant effects on the animal models.It was found that sodium channel site3-specific modulators named as BmK I and BmK αⅣ can induce strong epileptic behaviors and epileptiform discharges in the hippocampus[1,2].