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Functional inorganic nanoparticles have shown great potentials in diagnosing major diseases such as cancer,atherosclerosis,etc.Through past years,we have been developing versatile functional nanoparticles and nanoparticle-based probes for detecting tiny tumors and lymphatic micrometastasis,evaluating the vulnerability of atherosclerotic plaques,and visualizing tumor microenvironment abnormal signatures for understanding the malignant behaviors of cancers,apart from those for cancer theranostics.In this presentation,we will present our recent studies on above subjects.