【摘 要】
：
The family Flaviviridae comprises several major human pathogens including Hepatitis C virus (HCV, genus hepacivirus), yellow fever or dengue virus (genus flavivirus).The Flaviviridae genomes are made
【机 构】
：
Institut Pasteur France
【出 处】
：
2013百奥泰波兰重大疾病临床峰会
论文部分内容阅读
The family Flaviviridae comprises several major human pathogens including Hepatitis C virus (HCV, genus hepacivirus), yellow fever or dengue virus (genus flavivirus).The Flaviviridae genomes are made of a single stranded RNA segment that encodes a single polyprotein that is subsequently matured into some ten viral proteins.The non-structural proteins are released from the C-terminus of the polyprotein and participate during the intracellular part of the infectious cycle in transcribing and replicating the viral genome in the context of a membrane-bound multiprotein complex named the replication complex.Several of these non-structural proteins represent important targets against which specific antiviral inhibitors have been developed, several of which are currently used for therapy.X-ray crystal structures of these enzymes and more generally a deeper understanding of the molecular basis of their activities have helped powerfully in improving the antiviral compounds currently approved or in advanced clinical trials.For the latter molecules, a prime target is the RNAdependent RNA polymerase (RdRp, NS5B for HCV and pestiviruses, NS5 for flaviviruses).Here we report our current knowledge of the structural basis for viral RNA synthesis by NS5B and the perspectives it offers for further drug design.
其他文献
In Parkinsons disease (PD)、 resting tremor, postural tremor, or both often occur as initial symptoms.Levodopa and anticholinergic drugs have been used to manage tremor in PD.However, zonisamide (ZNS)
I will discuss the role microglia/macrophages may play after intracerebral hemorrhage (ICH) and ischemic stroke in scavenger receptor-mediated oxidative stress, phagocytes and inflammation.Specificall
The pathogenetic link between iron overload and diabetes or increased mortality may be exerted through iron-catalysed formation of hydroxyl radicals via the Fenton reaction and ensuing tissue oxidativ
Diabetes is a leading cause of chronic kidney disease (CKD).We ask if CKD progression is preventable by glycemic control with intensive insulin treatment.Data was obtained from 46 diabetic patients (2
Atypical antipsychotics (AAP) are prescribed to millions of patients with schizophrenia, bipolar disorder, major depression, and autism.Although AAP ameliorate mental dysfunctions, they have serious m
Temporal lobe epilepsy is one of the most common chronic neurological diseases.Imbalance the excitatory or inhibitory neurotransmitter release or disregulation of voltage-gated ion-channels supposed t
Obesity has increasing over the years in number of obese individuals and in severity of diseases.The physical activity is an important preventive factor and reducer of the effects of obesity and promo
V.iruses are responsible for disorders in humans, animals and plants.Murine sarcoma virus can induce cancer which is considered one of the leading worldwide causes of death.The early detection of canc
Objective: To study the incidence of bacteriuria and antimicrobial susceptibility pattern during pregnancy with no presenting symptoms of UTI Materials and Methods: The study was conducted among 411 p
Pronucleotides are consider as a new generation of anti-HIV pro-drugs.Their main advantage over recently used nucleoside analogues is that they by-pass one of the crucial bioactivation step, namely ph