【摘 要】
：
Temporal lobe epilepsy is one of the most common chronic neurological diseases.Imbalance the excitatory or inhibitory neurotransmitter release or disregulation of voltage-gated ion-channels supposed t
【机 构】
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Sechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of Science Russia
【出 处】
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2013百奥泰波兰重大疾病临床峰会
论文部分内容阅读
Temporal lobe epilepsy is one of the most common chronic neurological diseases.Imbalance the excitatory or inhibitory neurotransmitter release or disregulation of voltage-gated ion-channels supposed to be impetus for the seizure development.On the other hand.it was demonstrated that extracellular signal-regulated kinases 1 and 2 (ERK1/2) also participate in seizure devclopment.In our work we studied the effects of ERK1/2 inhibition by SL327 on seizure progression in the Krushinsky-Molodkina (KM) audiogenic seizure rats.The KM rats display generalized tonus-clonus seizures in response to intense sound stimulation.
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