The M-T Hook Structure Dramatically Increases the Potency of HIV-1 Fusion Inhibitors to Overcome Dru

• 作 者: 姚雪 崔胜
• 机 构: 医科院病原所
• 出 处: 中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议
• 发表日期: 2014年3期
• 关键词: HIV fusion inhibitor

Peptides derived from the C-terminal heptad repeat region (CHR) of HIV-1 gp41 are potentfusion inhibitors by targeting the N-terminal heptad repeat region (NHR).We have recentlyidentified that the unique M-T hook structure preceding the pocketbinding motifof CHR peptides can greatly enhance the binding of inhibitors to the NHR pocket thus improvingthe anti-HIV activity.