【摘 要】
：
Lupus nephritis affects up to 70% of patients with SLE.The etiology of lupus nephritis is multifactorial and remains to be fully defined.Accumulating eviden
【机 构】
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Department of Medicine,University of Hong Kong
【出 处】
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2015 International Symposium on Epigenetics and Autoimmunity
论文部分内容阅读
Lupus nephritis affects up to 70% of patients with SLE.The etiology of lupus nephritis is multifactorial and remains to be fully defined.Accumulating evidence suggests that anti-dsDNA antibodies play a critical role in the pathogenesis, through its direct binding to cross-reactive antigens on resident renal cells or indirect binding through chromatin material to extracellular matrix components, resulting in complement activation, cell activation and proliferation, and induction of inflammatory and fibrotic processes.
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