Co-delivery of doxorubicin and P-gp siRNA into human breast cancer cells by functionalized PLGA nano

• 作 者: TingtingLi;LiweiDeng;MinXu;XueShen;ChunhuiWu;YiyaoLiu;
• 机 构: Department of Biophysics,School of Life Science and Technology,University of Electronic Science and
• 出 处: The Third Symposium on Innovative Polymers for Controlled De
• 发表日期: 2014年期

　　Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy.One of the effective approaches to overcome MDR is to use nanoparticle-mediated gene silencing of chemotherapeutic export proteins by RNA interference to increase drug accumulation in drug resistant cancer cells [1,2].In this work,a new co-delivery system,DOX-PLGA/PEI/P-gp shRNA nanobubbles (NBs) around 427 nm,to overcome doxorubicin (DOX) resistance in MCF-7 human breast cancer was designed and developed.