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The current micellar drugs suffer a lot from low in vivo stability,premature drug release,inefficient tumor cell uptake,as well as slow drug release in the tumor site and inside the tumor cells,which would not only greatly reduce their therapeutic efficacy but also induce systemic side effects.Here,we report on cRGD-directed,NIR-responsive and robust AuNR/PEG-PCL hybrid nanoparticles (cRGD-HNs) for targeted chemotherapy of human glioma xenografts in mice [1].