Multiple functions of the first EGF domain in matrilin-3: Secretion and endoplasmic reticulum stress

• 作 者: YichunWang;JingshiLiu;ChenhuiLuo;ShengqiWu;ZurongLi;
• 机 构: The Affiliated Cancer Hospital of Xiangya Medical School,Central South University,Changsha 410013,Hu
• 出 处: 第十四届中南地区实验动物科技交流会
• 发表日期: 2014年期

　　Mutations in matrilin-3 have been associated with common skeletal diseases like Hand Osteoarthritis (HOA) as well as with the rare chondrodysplasias such as multiple epiphyseal dysplasia (MED) and spondylo-epi-metaphyseal dysplasia (SEMD).However, dedifferentiated chondrocytes of the third passage did not express it at all.Therefore, matrilin-3 might serve as a marker for the differentiation state of chondrocytes.These findings suggest that tight regulation of matrilin-3 expression is essential for maintenance of the cartilage ECM microenvironment.