Characterization of PERV in a new conserved pig herd as potential donor animals for xenotransplantat

• 作 者: FeiGuo[1]WeiXingxiao[2]WayneJHawthorne[3]QiongDong[1]BinYe[1]JuanZhang[1]QiLiang[1]WeiNie[1]WeiWang[1]
• 机 构: Cell Transplantation and Gene Therapy Institute of Central South University,Third Xiang-Ya Hospital
• 出 处: 第十四届中南地区实验动物科技交流会
• 发表日期: 2014年期

　　Background Xenotransplantation has drawn increased attention in recent years as a potential solution to the scarcity of human source donor organs.Researchers have highlighted the need to characterize the influence of porcine endogenous retroviruses (PERV) in xenotransplamation.Screening and analyzing the presence and subtype of PERV in donor source animal breeds could provide basic parameters to evaluate the biological safety of xenotransplantation from pigs to humans.We bred a new miniature porcine herd (XENO-1) after decades of investigation, the herd was bred to produce a potential donor animal source for xenotransplantation.