【摘 要】
：
AIM: Macrophage migration inhibitory factor (MIF) possesses proinflammatory function when secreted from the cells, it also exhibits antioxidant properties based on its intrinsic oxidoreductase activit
【机 构】
：
Medical Research center of Guangdong General Hospital,Guangdong Provincial Cardiovascular Institute,
【出 处】
：
中国病理生理学会心血管专业委员会第十五届学术大会暨国际心脏研究会中国分会第十二届学术大会
论文部分内容阅读
AIM: Macrophage migration inhibitory factor (MIF) possesses proinflammatory function when secreted from the cells, it also exhibits antioxidant properties based on its intrinsic oxidoreductase activity.However, the role of MIF in cardiac fibrosis is not well known.In the present study, the effect of MIF on fibrosis-associated gene expression and the underlying mechanism were examined.
其他文献
目的 探索粒径均一的负载全氟丙烷气体的复合脂质微胶囊(PHLM)造影剂的制备方法，观察其体内外显影效果.方法 以一种新型有机-无机复合脂质为原料，通过碳酸钙模板法和溶胶-凝胶自组装技术制备负载全氟丙烷气体的复合脂质微胶囊造影剂.电子显微镜观察其粒径与形态，体外细胞实验及溶血实验验证其生物相容性.体内超声实验以新西兰白兔为考察对象，通过耳缘静脉注射微胶囊观察其显影效果.结果 扫描电镜显示其形态为规则
目的 探讨微泡超声造影在子宫肌瘤诊断与鉴别诊断中的应用价值.方法 采用造影剂SonoVue联合造影匹配成像技术对19例子宫肌瘤患者进行实时超声造影检查.观察病灶内造影剂灌注过程及造影后声像图特征,分析时间-信号强度曲线,指标包括显影时间、达峰时间、基础峰值强度及半廓清时间,并与常规二维超声及手术病理结果对照.结果 19例子宫肌瘤中单发5例,多发14例,其中肌壁间肌瘤19个,浆膜下肌瘤10个,黏膜下
目的 探讨低强度聚焦超声体外局部靶向爆破脂质微泡的能力；探讨低强度聚焦超声体内定位靶向爆破载阿霉素新型微泡并更精确地定位释放药物的能力。方法 采用机械振荡法制备普通脂质微泡,将脂质微泡稀释后放入自制的乳胶水囊中,分别用同等强度的普通诊断超声和低强度聚焦超声辐照10 s后,采用二维超声显影模式观察普通诊断超声和低强度聚焦超声靶向破坏微泡的范围；选取20只健康新西兰大白兔,将新型载阿霉素微泡经兔耳缘静
目的 构建靶向PHD2基因的shRNA真核表达载体,探讨应用超声靶向破碎微泡联合PEI介导PHD2-shRNA转染对H9C2心肌细胞PHD2基因的沉默效应,及其间接促进HIF-1α和下游促血管生成因子(VEGF、TGF-β3及bFGF)基因表达的可行性.方法 构建靶向PHD2基因的shRNA真核表达质粒及对照质粒(单纯EGFP质粒).体外常氧、缺氧培养H9C2心肌细胞,分为4组：①对照质粒常氧组；
AIM: Hypertrophy is one of the common pathological characteristics in diverse cardiovascular diseases, such as hypertension,heart failure and cardiovalvulitis.MicroRNAs play an important role in many
AIM: Oxidative stress and intracellular Ca2+ overload are generally considered to be main factors responsible for ischemia/reperfusion (I/R) injury.However, the post-ischemic myocardial performance an
AIM: Hypertensive heart disease is the major cause of cardiovascular morbidity and mortality.Recent study has shown that TGFβ/Smad3 signaling plays a critical role in cardiac remodeling during the pro
AIM: Previous studies demonstrate that biological aging exerts a negative effect on the therapeutic effects of mesenchymal stem cell (MSC)-based therapy.Here, using a rat myocardial infarction (MI) mo
AIM: L-type calcium channel participates in the regulation of a variety of physical and pathological process.In vasculature, it mainly mediates agonist-induced vascular smooth muscle contraction.
AIM: Sepsis or septic shock is a severe complication after severe trauma or infection, and its morbidity and mortality were still high despite great development in medicine and techniques recent years