【摘 要】
：
有颌脊椎动物都可以通过剪接pre-mRNA而产生膜结合型免疫球蛋白M(mIgM)重链rnRNA.然而，四足类和辐鳍鱼类的剪接方式并不相同，前者跨膜区(TM)外显子连接于IgM CH4外显子近3末端的隐蔽剪切位点上，后者则表现出多种剪接样式：板鳃类膜型IgM的形成与四足类相似；软骨硬鳞鱼类包括IgM CH1-TM(3末端剪接)、CH3-TM(隐蔽剪接点剪接)和CH4-TM(隐蔽剪接点剪接)三种方式；
【机 构】
：
中国科学院水生生物研究所,淡水生态与生物技术国家重点实验室,武汉430072
【出 处】
：
中国水产学会鱼病学专业委员会2011年学术讨论会
论文部分内容阅读
有颌脊椎动物都可以通过剪接pre-mRNA而产生膜结合型免疫球蛋白M(mIgM)重链rnRNA.然而，四足类和辐鳍鱼类的剪接方式并不相同，前者跨膜区(TM)外显子连接于IgM CH4外显子近3末端的隐蔽剪切位点上，后者则表现出多种剪接样式：板鳃类膜型IgM的形成与四足类相似；软骨硬鳞鱼类包括IgM CH1-TM(3末端剪接)、CH3-TM(隐蔽剪接点剪接)和CH4-TM(隐蔽剪接点剪接)三种方式；全骨鱼类除了具有类似软骨硬鳞鱼类的CH3-TM和CH4-TM的膜型IgM剪接体，还能形成CH3-TM(3末端剪接)mIgM；相比较而言，大多数真骨鱼类膜型IgM剪接形式显得单一，仅发现CH3-TM(3末端剪接)样式.
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