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Open tubular liquid or ion chromatography is efficient only in very small capillaries,smaller than those used in capillary electrophoresis.Problems of suitably small volume injection,making aseparation column and detecting sensitively are all very significant.In recent years we have learned how to inject fL-multi-nL volumes of samples in the same setup,generate active chromatographic surfaces within capillaries as small as 5 μm in bore and learned to make inexpensive detectors to detect analytes sensitively in such small tubes.The prospects of working meaningfully with practical inexpensive equipment(less than $1000 for a high performance chromatograph!)are alluring and we have come far.We will describe the technique,the instrumentation and the results.