Estrogen receptor βexpression in the embryonic brain regulates development of calretinin-immunoreact

• 作 者: XiaotangFAN[1]MargaretWARNER[2]Jan-AkeGUSTAFSSON[2]
• 机 构: Division of Medical Nutrition, Department of Biosciences and Nutrition, Karolinska Institutet, Novum
• 出 处: 中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
• 发表日期: 2007年期

　　Our previous studies with ERβ(--) mice demonstrated that ERβ is necessary for embryonic development of the brain as early as E14.5 and is involved in neuronal migration.Such early effects of estrogen receptors were unexpected because estradiol synthesis and action in the brain are well documented to occur at E18.5.Since the presence of ERβ in the embryonic brain was not demonstrated it remained possible that the developmental abnormalities in ERβ(--) mice were due to indirect effects of estrogen action on the brain.In the present study we examined the distribution of ERβ in the developing brain and identified a population of ERβ-regulated intemeurons.ERβ appears in the brain at E12.5,mainly localized in the wall of midbrain,neuromere,hypothalamus,thalamus and basal plate of pons.