ICON,a 3D-reconstruction algorithm using compressed sensing approach and its application in electron

来源 :第四届全国冷冻电子显微学与结构生物学专题研讨会 | 被引量 : 0次 | 上传用户：ustczhy

【摘要】

：

Cryo-electron tomography(ET) plays an important role in revealing biological structures,ranging from macromolecule scale to subcellular scale.After acquiring se

【作者】

：

Yuchen Deng Yu Chen Yan Zhang Fa Zhang Fei Sun

【机构】

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NationalKeyLaboratoryofBiomacromolecules,InstituteofBiophysics,ChineseAcademyofSciences,Beijing10010

【出处】

：

第四届全国冷冻电子显微学与结构生物学专题研讨会

【发表日期】

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2015年6期

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Cryo-electron tomography(ET) plays an important role in revealing biological structures,ranging from macromolecule scale to subcellular scale.After acquiring series of pictures with different angular assignment,one performs an inverse radon transform and gets the 3D structure of biological specimen.However,since high angle tilt image cannot be acquired with respect to certain physical limits,ET reconstruction suffers from a well-known bias called ‘missing wedge’,which makes ET reconstruction as a kind of ‘ill-posed’ problem.

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