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本实验采用大鼠球囊内皮剥脱模型研究表明，内皮损伤后可导致内膜增厚，但内皮损伤后每日游泳６０分钟，共游泳２周，大鼠组比内皮损伤后非游泳组内膜增生厚度、面积和细胞数分别降低了５４．７％，４８．７％和５１．５％（Ｐ＜０．０１）；动脉血管环对ＡＣＨ的舒张反应性提高（Ｐ＜０．０１）；血管组织ｃＧｍＰ水平提高５８．３％（Ｐ＜０．０１）。提示运动可明显抑制动脉内皮损伤后增殖反应的第１、２高峰期；血管内皮释放内皮舒张因子增多可能是运动抑制内皮损伤后增殖反应的机制之一。
This experiment using rat balloon endothelial stripping model studies showed that endothelial injury can lead to thickening of the intima, but the end of the injury after swimming 60 minutes a day, swimming a total of 2 weeks, the rat group than the endothelial injury non-swimming group intima The thickness, area and number of proliferating cells decreased by 54.7%, 48.7% and 51.5%, respectively (P <0.01). The vasorelaxation of ACH was enhanced by arterial rings (P <0.01). The level of cGmP in vascular tissue increased by 58.3% (P <0.01). Suggesting that exercise can significantly inhibit the first and second peak of proliferative response after arterial endothelial injury. The increase of endothelial relaxing factor released by vascular endothelium may be one of the mechanisms by which exercise inhibits the proliferative response after endothelial injury.