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多发性硬化症(MS)的病因目前还不清楚,但近年,MS 的自身免疫病因学说和慢性病毒感染学说越来越受到重视。免疫与病毒感染有着密切的联系。现将自身免疫病因学方面的研究综述如下:认为MS 为自身免疫疾病的主要根据:(1)脑脊液中的γ—球蛋白增多;(2)以荧光抗体法,可见到病灶部位有高浓度的γ—球蛋白沉着,(3)MS 急性期病灶以淋巴细胞、浆细胞浸润为主;(4)在试管内,以组织培养方法,能从急性期MS 血清中证实脱髓鞘抗体,(5)实验性变态反应性脑脊髓炎
The etiology of multiple sclerosis (MS) is not yet clear, but in recent years, MS’s theory of autoimmune etiology and chronic viral infection is more and more attention. Immune and viral infections are closely linked. Now the etiology of autoimmune studies are summarized as follows: MS is considered the main basis for autoimmune diseases: (1) cerebrospinal fluid γ-globulin increased; (2) by fluorescent antibody method, we can see the high concentration of lesions γ-globin deposition, (3) acute lymphocyte and plasma cell infiltration in MS lesions; (4) Demyelinating antibodies were confirmed from acute MS sera by tissue culture in vitro Experimental Allergic Encephalomyelitis