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目的 :探讨原发性高血压 (EH)患者 2 4h平均脉压 (PP)与靶器官损害 (TOD)的关系。方法 :对 5 8例EH患者进行 2 4h无创性动态血压监测 ,并根据有无左室肥厚 (LVH)分为两组 :非LVH组 (2 1例 )、LVH组(37例 ) ,其中LVH伴心功能不全者 17例 ,心功能正常者 2 0例进行观察。结果 :①LVH组心功能正常者 2 4h平均收缩压 (SBP)、2 4h平均PP显著大于非LVH组 (P <0 .0 1) ;②左室质量指数、相对室壁厚度与 2 4h平均SBP、PP呈正相关 (P <0 .0 1) ;③LVH组伴或不伴心功能不全者 2 4h平均SBP、PP明显高于非LVH组 (P <0 .0 1) ,LVH组伴心功能不全者 2 4h平均PP高于LVH心功能正常组 (P <0 .0 5 )。结论 :2 4h平均PP增大在EH伴LVH的发展中起作用 ,且对靶器官损害程度有预测价值
Objective: To investigate the relationship between mean arterial pressure (PP) and target organ damage (TOD) at 24 hours in patients with essential hypertension (EH). Methods Fifty-eight patients with EH underwent 24-h noninvasive ambulatory blood pressure monitoring and were divided into two groups according to the presence or absence of left ventricular hypertrophy (LVH): non-LVH group (n = 21) and LVH group (n = 37) 17 cases with cardiac dysfunction, normal heart function 20 cases were observed. Results: (1) The average systolic blood pressure (SBP) at 24 hours in normal LVH group was significantly higher than that in non-LVH group at 24 hours (P <0.01); ② The left ventricular mass index, relative wall thickness and mean SBP , PP were positively correlated (P <0.01) .③The average SBP and PP in 24 h group with or without LVH were significantly higher than those in non-LVH group (P <0.01). LVH group with cardiac dysfunction The mean PP in 24 hours was higher than that in LVH normal heart group (P <0.05). CONCLUSION: The mean increase in PP in 24 hours plays a role in the development of EH accompanied by LVH, and has predictive value for the degree of target organ damage