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本研究旨在观察褪黑素 ( MT)对大鼠“阿霉素肾病”的保护作用 .将所有受试动物分为 5组 ,即正常组 ,MT( d0 - d7,5mg·kg-1·d-1,ig)组 ,多柔比星模型组 ( d 1 ,Dox,5mg· kg-1,iv)组和MT( d 0 - d 7,0 .5,5mg· kg-1· d-1) + Dox( d 1 ,5mg· kg-1,iv)组 .检测大鼠 d7,d1 4,d2 1和 d2 8时尿蛋白 ,尿丙二醛排泄量和 d 2 8时血浆生化指标 .结果显示 ,Dox组大鼠呈典型的肾病综合征 ,MT+ Dox组大鼠尿蛋白减少 ,血浆蛋白明显回升 ,血脂降低 ;同时 ,Dox组动物尿丙二醛显著增加 ,MT+ Dox组丙二醛降低 .这些结果表明 ,MT可减轻“阿霉素肾病”大鼠肾损害 .
This study aimed to observe the protective effect of melatonin (MT) on adriamycin-induced nephropathy in rats.All the animals were divided into 5 groups: normal group, MT (d0-d7,5mg · kg-1 · (d 1, Dox, 5 mg · kg -1, iv) and MT (d 0 -d 7, 0.5, 5 mg · kg -1 · d- 1) + Dox group (d 1, 5 mg · kg -1, iv), and the urinary malondialdehyde (MDA) excretion and the plasma biochemical parameters at d 2 8 were measured at d7, d1 4, d2 1 and d2 8. The results showed that the rats in Dox group showed a typical nephrotic syndrome, the urinary protein decreased, the plasma protein increased significantly, and the blood lipid decreased in MT + Dox group; meanwhile, the urinary malonaldehyde increased significantly in Dox group and the malondialdehyde decreased in MT + Dox group These results indicate that MT can reduce renal damage in “doxorubicin nephropathy” rats.