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研究 1 ,6-二磷酸果糖镁 ( FDP- Mg)对异丙肾上腺素 ( Iso)所致心肌损伤的保护作用 .大鼠 sc Iso( 8mg· kg-1· d-1,3d)造成心肌损伤模型 ,测定心肌组织和血清肌酸激酶 ( CK) ,乳酸脱氢酶( LDH) ,超氧化物歧化酶 ( SOD)活性及丙二醛( MDA) ,Mg2 + ,P和 K+ 含量 .结果 :每天给予 Iso的同时给予 FDP- Mg( 2 50 - 1 0 0 0 mg· kg-1· d-1,3d)能明显降低血清 CK,LDH水平 ,抑制心肌组织中 CK,LDH释放 ,提高血清和心肌 SOD活性 ,降低MDA水平 ,提高心肌及血清 Mg2 +和 P含量 ,降低血清 K+浓度。综合了 FDP- Na2 ( 530 mg· kg-1·d-1,3d)和硫酸镁 ( 1 50 mg· kg-1· d-1,3d)的作用特点。结果表明 ,FDP- Mg对 Iso所致大鼠心肌损伤具有保护作用 ,与其抗氧化及改善心肌代谢有关 .
To study the protective effect of fructose-1, 6-diphosphate (FDP-Mg) on myocardial injury induced by isoproterenol (Iso), and myocardial injury induced by sc Iso (8 mg · kg-1 · d-1, 3d) (CK), lactate dehydrogenase (LDH), superoxide dismutase (SOD) activity and malondialdehyde (MDA), Mg2 +, P and K + contents in myocardial tissue and serum were determined.Results: Administration of Iso with FDP-Mg (2 50-1 200 mg · kg -1 · d-1, 3d) significantly reduced serum CK and LDH levels, inhibited the release of CK and LDH in myocardium, increased serum and myocardium SOD activity, decreased MDA level, increased myocardial and serum Mg2 + and P levels, decreased serum K + concentration. The combination of FDP-Na2 (530 mg · kg-1 · d-1, 3d) and magnesium sulfate (1 50 mg · kg-1 · d-1, 3d) The results showed that FDP-Mg had a protective effect on Iso-induced myocardial injury in rats, which was related to its antioxidation and myocardial metabolism.