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用静式染毒室,以1 600-1 900mg/m~3浓度的CS_2将19只大白鼠染毒,每天6小时,每周六天,历时八周。用Fullerton法测定大白鼠坐骨神经MCV,染毒前为50.91+8.45m/s,染毒3周时,减慢到41.63+6.83m/s,相当于同期对照组的75.8％(P<0.001);停止染毒后,经过12周的恢复,达到51.60+9.92m/s,已恢复到染毒前水平。用Seppülüinen法测定大白鼠坐骨神经MCV,染毒前为25.51+3.72m/s,在染毒期间,仅有轻微减慢,停止染毒后的第7周,减慢到20.71+2.65m/s,相当于同期对照组的75.4％(P<0.001)。经过18周的恢复,达到24.43+3.54m/s,相当于同期对照组的88.1％(P<0.05)。 比较两种测定MCV的结果可看出,CS_2不仅能损伤脊髓前角细胞和轴突,还损伤运动终板和肌肉。 用标准MCV测定技术测定MCV对早期诊断CS_2神经病是个有用的指标。测定CS_2接触者的末端潜伏期,对了解治疗期间和恢复期间病人的情况也许是更有意义的。
Nineteen rats were exposed to CS 2 at a concentration of 600-1 900 mg / m 3 for 6 hours a day, six days a week for eight weeks. The sciatic nerve MCV was measured by Fullerton method in 50.91 + 8.45m / s before exposure and 41.63 + 6.83m / s at 3 weeks, which was 75.8% (P <0.001) of the control group. After stopping the exposure, after 12 weeks of recovery, reaching 51.60 +9.92m / s, has returned to pre-exposure levels. The sciatic nerve MCV of rats was measured by Seppülüinen method. The exposure time was 25.51 + 3.72m / s before exposure and only slightly slowed down during the exposure period. At the seventh week after application, the MCV was slowed down to 20.71 + 2.65m / s, Equivalent to 75.4% of the control group over the same period (P <0.001). After 18 weeks of recovery, it reached 24.43 + 3.54m / s, equivalent to 88.1% of the control group (P <0.05). Comparing the results of two kinds of determination of MCV, it can be seen that CS_2 can not only damage the spinal cord anterior horn cells and axons, but also damage the motor end plate and muscle. The determination of MCV by standard MCV assay is a useful indicator for the early diagnosis of CS_2 neuropathy. Determining the terminal latency of CS2 contacts may be more relevant to understanding the patient’s condition during and during recovery.