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本文提出了片剂或胶囊中丙基硫尿嘧啶的紫外分光测定法。该法比美国药典的测定法准确,精密,简便及快速,可用于溶化速度的研究。丙基硫尿嘧啶溶于水或微酸性溶液中,在275毫微米处有最大吸收。在此波长的吸收系数约为98.6 L/克-厘米。此吸收系数可用于该药在37℃人造胃液中溶化作用的研究。测定方法:取20片,磨成粉末,精密称取相当50毫克的丙基硫尿嘧啶,置100毫升容量瓶中,对软胶囊(50毫克丙基硫尿嘧啶/粒)取1颗置100毫升容量瓶中,加水25毫
This paper presents UV spectrophotometry of propylthiouracil in tablets or capsules. The method than the United States Pharmacopoeia accurate, precise, simple and fast, can be used for melting speed research. Propylthiouracil is soluble in water or slightly acidic solution with maximum absorption at 275 nm. The absorption coefficient at this wavelength is about 98.6 L / g-cm. The absorption coefficient can be used for the drug in 37 ℃ artificial gastric juice melting effect. Determination: Take 20, ground into powder, accurately weighed 50 mg of propylthiouracil, placed in 100 ml volumetric flask, soft gelatin capsules (50 mg propylthiouracil / grain) to take a set of 100 Ml flask, add water 25 milliliters