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作者在前文中已报导Sb-57和Sb-71对数种动物肿瘤有一定的疗效,其中Sb-71对Ehrlich腹水瘤的疗效較好。这种新类型的化合物在肿瘤的化学治疗上是值得注意的一个方向。进一步研究它在体內的分布与排泄,不但可为临床試用提供資料,同时对闡明其作用机制也有帮助。本实驗室已介紹一些巯基化合物可以解除Sb-71的疗效及毒性,似乎Sb在Sb-71的疗效机制中起着重要的作用,但是否如此,还需要进一步提供
The authors have previously reported that Sb-57 and Sb-71 have some effect on several animal tumors, of which Sb-71 has a good effect on Ehrlich ascites tumor. This new class of compounds is a noteworthy direction in the chemotherapy of tumors. Further study of its distribution in the body and excretion, not only for the clinical trial to provide information, at the same time to clarify its mechanism of action is also helpful. It has been reported that some sulfhydryl compounds can relieve the efficacy and toxicity of Sb-71 in our laboratory. It seems that Sb plays an important role in the therapeutic mechanism of Sb-71. However, it is necessary to further provide